Publications, Awards, & Appearances
Featured Publications
Balanced T and B cell responses are required for immune protection against Powassan virus in virus-like particle vaccination
E Taylor Stone Mariah Hassert Elizabeth Geerling, Colleen Wagner James D Brien Gregory D Ebel, Alec J Hirsch Cody German Jessica L Smith Amelia K Pinto
“Powassan virus (POWV) is a tick-borne pathogen for which humans are an incidental host. POWV infection can be fatal or result in long-term neurological sequelae; however, there are no approved vaccinations for POWV. Integral to efficacious vaccine development is the identification of correlates of protection, which we accomplished in this study by utilizing a murine model of POWV infection. Using POWV lethal and sub-lethal challenge models, we show that (1) robust B and T cell responses are necessary for immune protection, (2) POWV lethality can be attributed to both viral- and host-mediated drivers of disease, and (3) knowledge of the immune correlates of protection against POWV can be applied in a virus-like particle (VLP)-based vaccination approach that provides protection from lethal POWV challenge. Identification of these immune protection factors is significant as it will aid in the rational design of POWV vaccines.
Obesity Enhances Disease Severity in Female Mice Following West Nile Virus Infection
Elizabeth Geerling E Taylor Stone Tara L Steffen Mariah Hassert James D Brien Amelia K Pinto
A rise in adiposity in the United States has resulted in more than 70% of adults being overweight or obese, and global obesity rates have tripled since 1975. Following the 2009 H1N1 pandemic, obesity was characterized as a risk factor that could predict severe infection outcomes to viral infection. Amidst the SARS-CoV-2 pandemic, obesity has remained a significant risk factor for severe viral disease as obese patients have a higher likelihood for developing severe symptoms and requiring hospitalization. However, the mechanism by which obesity enhances viral disease is unknown. In this study, we utilized a diet-induced obesity mouse model of West Nile virus (WNV) infection, a flavivirus that cycles between birds and mosquitoes and incidentally infects both humans and mice. Likelihood for severe WNV disease is associated with risk factors such as diabetes that are comorbidities also linked to obesity. Utilizing this model, we showed that obesity-associated chronic inflammation increased viral disease severity as obese female mice displayed higher mortality rates and elevated viral titers in the central nervous system. In addition, our studies highlighted that obesity also dysregulates host acute adaptive immune responses, as obese female mice displayed significant dysfunction in neutralizing antibody function. These studies highlight that obesity-induced immunological dysfunction begins at early time points post infection and is sustained through memory phase, thus illuminating a potential for obesity to alter the differentiation landscape of adaptive immune cells.”
Current Flavivirus Research Important for Vaccine Development
Geerling E, Steffen TL, Brien JD, Pinto AK
“The Flaviviridae family of RNA viruses includes numerous human disease-causing pathogens that largely are increasing in prevalence due to continual climate change, rising population sizes and improved ease of global travel. Escalating circulation of these emerging and re-emerging pathogens draws attention to the need for vaccines to protect against the severe diseases they cause, and this need is further exacerbated by their transmission that occurs primarily through arthropod vectors. When constructing new, efficacious vaccine candidates, several goals are targeted including safety, protective capacity, ability to confer sustained protection, induction of neutralizing antibody and protective T cell responses, as well as practicality.”
All Publications from Pinto Laboratory by Year
2022
Karger AB, Brien JD, Christen JM, Dhakal S, Kemp TJ, Klein SL, Pinto LA, Premkumar L, Roback JD, Binder RA, Boehme KW, Boppana S, Cordon-Cardo C, Crawford JM, Daiss JL, Dupuis AP, Espino AM, Firpo-Betancourt A, Forconi C, Forrest JC, Girardin RC, Granger DA, Granger SW, Haddad NS, Heaney CD, Hunt DT, Kennedy JL, King CL, Krammer F, Kruczynski K, LaBaer J, Lee FE, Lee WT, Liu SL, Lozanski G, Lucas T, Mendu DR, Moormann AM, Murugan V, Okoye NC, Pantoja P, Payne AF, Park J, Pinninti S, Pinto AK, Pisanic N, Qiu J, Sariol CA, Simon V, Song L, Steffen TL, Stone ET, Styer LM, Suthar MS, Thomas SN, Thyagarajan B, Wajnberg A, Yates JL, Sobhani K. The Serological Sciences Network (SeroNet) for COVID-19: Depth and Breadth of Serology Assays and Plans for Assay Harmonization.medRxiv. 2022 Mar 14:2022.02.27.22271399. doi: 10.1101/2022.02.27.22271399. Preprint.PMID: 35262095
Stone ET, Hassert M, Geerling E, Wagner C, Brien JD, Ebel GD, Hirsch AJ, German C, Smith JL, Pinto AKBalanced T and B cell responses are required for immune protection against Powassan virus in virus-like particle vaccination..Cell Rep. 2022 Feb 15;38(7):110388. doi: 10.1016/j.celrep.2022.110388.PMID: 35172138
Geerling E, Pinski AN, Stone ET, DiPaolo RJ, Zulu MZ, Maroney KJ, Brien JD, Messaoudi I, Pinto AK. Roles of antiviral sensing and type I interferon signaling in the restriction of SARS-CoV-2 replication.iScience. 2022 Jan 21;25(1):103553. doi: 10.1016/j.isci.2021.103553. Epub 2021 Dec 3.PMID: 34877479
Nasr MC, Geerling E, Pinto AK Impact of Obesity on Vaccination to SARS-CoV-2. Front Endocrinol (Lausanne). 2022 Jun 20;13:898810. doi: 10.3389/fendo.2022.898810. eCollection 2022.PMID: 35795152 .
Pike DP, McGuffee RM, Geerling E, Albert CJ, Hoft DF, Shashaty MGS, Meyer NJ, Pinto AK, Ford DA Plasmalogen Loss in Sepsis and SARS-CoV-2 Infection. Front Cell Dev Biol. 2022 Jun 6;10:912880. doi: 10.3389/fcell.2022.912880. eCollection 2022.PMID: 35784479
Geerling E, Hameed M, Weger-Lucarelli J, Pinto AK..Metabolic syndrome and aberrant immune responses to viral infection and vaccination: Insights from small animal models.Front Immunol. 2022 Nov 30;13:1015563. doi: 10.3389/fimmu.2022.1015563. eCollection 2022.PMID: 36532060
Hameed M, Geerling E, Pinto AK, Miraj I, Weger-Lucarelli Immune response to arbovirus infection in obesity. J.Front Immunol. 2022 Nov 18;13:968582. doi: 10.3389/fimmu.2022.968582. eCollection 2022.PMID: 36466818
Geerling E, Murphy V, Mai MC, Stone ET, Casals AG, Hassert M, O'Dea AT, Cao F, Donlin MJ, Elagawany M, Elgendy B, Pardali V, Giannakopoulou E, Zoidis G, Schiavone DV, Berkowitz AJ, Agyemang NB, Murelli RP, Tavis JE, Pinto AK, Brien JD.Metal coordinating inhibitors of Rift Valley fever virus replication. PLoS One. 2022 Sep 16;17(9):e0274266. doi: 10.1371/journal.pone.0274266. eCollection 2022.PMID: 36112605
Marzan-Rivera N, Serrano-Collazo C, Cruz L, Pantoja P, Ortiz-Rosa A, Arana T, Martinez MI, Burgos AG, Roman C, Mendez LB, Geerling E, Pinto AK, Brien JD, Sariol CA Infection order outweighs the role of CD4+ T cells in tertiary flavivirus exposure. iScience. 2022 Jul 16;25(8):104764. doi: 10.1016/j.isci.2022.104764. eCollection 2022 Aug 19.PMID: 35982798
Stone ET, Hirsch AJ, Smith JL, Brien JD, Pinto AK Titration and neutralizing antibody quantification by focus forming assay for Powassan virus. STAR Protoc. 2022 Jun 17;3(3):101473. doi: 10.1016/j.xpro.2022.101473. eCollection 2022 Sep 16.PMID: 35755126
2021
Pinski AN, Steffen TL, Zulu MZ, George SL, Dickson A, Tifrea D, Maroney KJ, Tedeschi N, Zhang Y, Scheuermann RH, Pinto AK, Brien JD, Messaoudi ICorticosteroid treatment in COVID-19 modulates host inflammatory responses and transcriptional signatures of immune dysregulation.J Leukoc Biol. 2021 Dec;110(6):1225-1239. doi: 10.1002/JLB.4COVA0121-084RR. Epub 2021 Nov 3.PMID: 34730254
Pinto AK, Hassert M, Han X, Barker D, Carnelley T, Branche E, Steffen TL, Stone ET, Geerling E, Viramontes KM, Nykiforuk C, Toth D, Shresta S, Kodihalli S, Brien JD.The Ability of Zika virus Intravenous Immunoglobulin to Protect From or Enhance Zika Virus Disease.Front Immunol. 2021 Sep 6;12:717425. doi: 10.3389/fimmu.2021.717425. eCollection 2021.PMID: 34552587
Geerling E, Stone ET, Steffen TL, Hassert M, Brien JD, Pinto AK Obesity Enhances Disease Severity in Female Mice Following West Nile Virus Infection..Front Immunol. 2021 Aug 31;12:739025. doi: 10.3389/fimmu.2021.739025. eCollection 2021.PMID: 34531877
Hassert M, Steffen TL , Scroggins S , Coleman AK , Shacham E , Brien JD , Pinto AK. Prior heterologous flavivirus exposure results in reduced pathogenesis in a mouse model of Zika virus infection. J Virol. 2021 Jun 2:JVI0057321. doi: 10.1128/JVI.00573-21. Online ahead of print.PMID: 34076486
Wollner CJ, Richner M, Hassert M, Pinto AK, Brien JD, Richner JM.A Dengue Virus Serotype 1 mRNA-LNP Vaccine Elicits Protective Immune Responses. J Virol. 2021 Mar 24:JVI.02482-20. doi: 10.1128/JVI.02482-20. Online ahead of print. PMID: 33762420
King RG, Silva-Sanchez A, Peel JN, Botta D, Dickson AM, Pinto AK, Meza-Perez S, Allie SR, Schultz MD, Liu M, Bradley JE, Qiu S, Yang G, Zhou F, Zumaquero E, Simpler TS, Mousseau B, Killian JT Jr, Dean B, Shang Q, Tipper JL, Risley CA, Harrod KS, Feng T, Lee Y, Shiberu B, Krishnan V, Peguillet I, Zhang J, Green TJ, Randall TD, Suschak JJ, Georges B, Brien JD, Lund FE, Roberts MS Single-Dose Intranasal Administration of AdCOVID Elicits Systemic and Mucosal Immunity against SARS-CoV-2 and Fully Protects Mice from Lethal Challenge. Vaccines (Basel). 2021 Aug 9;9(8):881. doi: 10.3390/vaccines9080881.PMID: 34452006
Grady SF, Pinto AK, Hassert M, D'Angelo JA, Brien JD, Arnatt CK Selective estrogen receptor modulator, tamoxifen, inhibits Zika virus infection..J Med Virol. 2021 Nov;93(11):6155-6162. doi: 10.1002/jmv.27230. Epub 2021 Aug 4.PMID: 34314058
Khojandi N, Kuehm LM, Piening A, Donlin MJ, Hsueh EC, Schwartz TL, Farrell K, Richart JM, Geerling E, Pinto AK, George SL, Albert CJ, Ford DA, Chen X, Kline J, Teague RM.Oxidized Lipoproteins Promote Resistance to Cancer Immunotherapy Independent of Patient Obesity. Cancer Immunol Res. 2021 Feb;9(2):214-226. doi: 10.1158/2326-6066.CIR-20-0358. Epub 2020 Dec 10. PMID: 33303575
Sariol CA, Pantoja P, Serrano-Collazo C, Rosa-Arocho T, Armina-Rodríguez A, Cruz L, Stone ET, Arana T, Climent C, Latoni G, Atehortua D, Pabon-Carrero C, Pinto AK, Brien JD, Espino AM.Function Is More Reliable than Quantity to Follow Up the Humoral Response to the Receptor-Binding Domain of SARS-CoV-2-Spike Protein after Natural Infection or COVID-19 Vaccination. Viruses. 2021 Sep 30;13(10):1972. doi: 10.3390/v13101972.PMID: 34696403
2020
Hassert M, Geerling E, Stone ET, Steffen TL, Feldman MS, Dickson AL, Class J, Richner JM, Brien JD, Pinto AK. mRNA induced expression of human angiotensin-converting enzyme 2 in mice for the study of the adaptive immune response to severe acute respiratory syndrome coronavirus 2.PLoS Pathog. 2020 Dec 16;16(12):e1009163. doi: 10.1371/journal.ppat.1009163. Online ahead of print. PMID: 33326500.
Patra T, Meyer K, Geerling L, Isbell TS, Hoft DF, Brien J, Pinto AK, Ray RB, Ray R. SARS-CoV-2 spike protein promotes IL-6 trans-signaling by activation of angiotensin II receptor signaling in epithelial cells. PLoS Pathog. 2020 Dec 7;16(12):e1009128. doi: 10.1371/journal.ppat.1009128. eCollection 2020 Dec.PMID: 33284859 .
Vijayalingam S, Ezekiel UR, Xu F, Subramanian T, Geerling E, Hoelscher B, San K, Ganapathy A, Pemberton K, Tycksen E, Pinto AK, Brien JD, Beck DB, Chung WK, Gurnett CA, Chinnadurai G. Human iPSC-Derived Neuronal Cells From CTBP1-Mutated Patients Reveal Altered Expression of Neurodevelopmental Gene Networks. Front. Neurosci. 2020 Oct 27;14:562292. doi: 10.3389/fnins.2020.562292. eCollection 2020.PMID: 33192249
Stone ET, Geerling E, Steffen TL, Hassert M, Dickson A, Spencer JF, Toth K, DiPaolo RJ, Brien JD, Pinto AK. Characterization of cells susceptible to SARS-COV-2 and methods for detection of neutralizing antibody by focus forming assay. bioRxiv. 2020:2020.08.20.259838. doi: 10.1101/2020.08.20.259838.
Dussupt V, Sankhala RS, Gromowski GD, Donofrio G, De La Barrera RA, Larocca RA, Zaky W, Mendez-Rivera L, Choe M, Davidson E, McCracken MK, Brien JD, Abbink P, Bai H, Bryan AL, Bias CH, Berry IM, Botero N, Cook T, Doria-Rose NA, Escuer AGI, Frimpong JA, Geretz A, Hernandez M, Hollidge BS, Jian N, Kabra K, Leggat DJ, Liu J, Pinto AK, Rutvisuttinunt W, Setliff I, Tran U, Townsley S, Doranz BJ, Rolland M, McDermott AB, Georgiev IS, Thomas R, Robb ML, Eckels KH, Barranco E, Koren M, Smith DR, Jarman RG, George SL, Stephenson KE, Barouch DH, Modjarrad K, Michael NL, Joyce MG, Krebs SJ. Potent Zika and dengue cross-neutralizing antibodies induced by Zika vaccination in a dengue-experienced donor. Nat Med. 2020 Feb;26(2):228-235. doi: 10.1038/s41591-019-0746-2. Epub 2020 Feb 3. PMID: 32015557
Hassert M, Wolf KJ, Rajeh A, Schiebout C, Hoft SG, Ahn TH, DiPaolo RJ, Brien JD, Pinto AK. Diagnostic differentiation of Zika and dengue virus exposure by analyzing T cell receptor sequences from peripheral blood of infected HLA-A2 transgenic mice. PLoS Negl Trop Dis. 2020 Dec 3;14(12):e0008896. doi: 10.1371/journal.pntd.0008896. eCollection 2020 Dec.PMID: 33270635
Geerling E, Steffen TL, Brien JD, Pinto AK. Current Flavivirus Research Important for Vaccine Development. Vaccines (Basel). 2020 Aug 27;8(3):477. doi: 10.3390/vaccines8030477. PMID: 32867038
Steffen TL, Stone ET, Hassert M, Geerling E, Grimberg BT, Espino AM, Pantoja P, Climent C, Hoft DF, George SL, Sariol CA, Pinto AK, Brien JD. The receptor binding domain of SARS-CoV-2 spike is the key target of neutralizing antibody in human polyclonal sera. bioRxiv. 2020:2020.08.21.261727. doi: 10.1101/2020.08.21.261727. (Co-corresponding)
Serrano-Collazo C, Perez-Guzman EX, Pantoja P, Hassert MA, Rodriguez IV, Giavedoni L, Hodara V, Parodi L, Cruz L, Arana T, Martinez MI, White L, Brien JD, de Silva A, Pinto AK, Sariol CA. Effective control of early Zika virus replication by Dengue immunity is associated to the length of time between the 2 infections but not mediated by antibodies. PLoS Negl Trop Dis. 2020;14(5):e0008285. Epub 2020/05/29. doi: 10.1371/journal.pntd.0008285. PubMed PMID: 32463814; PMCID: PMC7255596.
Steffen T, Hassert M, Hoft SG, Stone ET, Zhang J, Geerling E, Grimberg BT, Roberts MS, Pinto AK, Brien JD. Immunogenicity and Efficacy of a Recombinant Human Adenovirus Type 5 Vaccine against Zika Virus. Vaccines (Basel). 2020;8(2). Epub 2020/04/11. doi: 10.3390/vaccines8020170. PubMed PMID: 32272595; PMCID: PMC7349816.
de Oliveira LC, Ribeiro AM, Albarnaz JD, Torres AA, Guimarães LFZ, Pinto AK, Parker S, Doronin K, Brien JD, Buller MR, Bonjardim CA.The small molecule AZD6244 inhibits dengue virus replication in vitro and protects against lethal challenge in a mouse model.Arch Virol. 2020 Mar;165(3):671-681. doi: 10.1007/s00705-020-04524-7. Epub 2020 Jan 16. PMID: 31942645
2019
Time elapsed between Zika and dengue virus infections affects antibody and T cell responses. Pérez-Guzmán EX, Pantoja P, Serrano-Collazo C, Hassert MA, Ortiz-Rosa A, Rodríguez IV, Giavedoni L, Hodara V, Parodi L, Cruz L, Arana T, White LJ, Martínez MI, Weiskopf D, Brien JD, de Silva A, Pinto AK, Sariol CA.
Isolation and Quantification of Zika Virus from Multiple Organs in a Mouse. Brien, J. D., Hassert, M., Stone, E. T., Geerling, E., Cruz-Orengo, L., Pinto, A. K. J. Vis. Exp. 150, e59632. (2019) doi:10.3791/59632
Identification of Protective CD8 T Cell Responses in a Mouse Model of Zika Virus Infection. Mariah Hassert, Madison G. Harris, James D. Brien, and Amelia K. Pinto. Front. Immunol., 17 July 2019 | https://doi.org/10.3389/fimmu.2019.01678
Mouse Models of Heterologous Flavivirus Immunity: A Role for Cross-Reactive T Cells. Mariah Hassert, James D. Brien, and Amelia K. Pinto. Front. Immunol., 09 May 2019 | https://doi.org/10.3389/fimmu.2019.01045
2018
CD4+T cells mediate protection against Zika associated severe disease in a mouse model of infection. Hassert M, Wolf KJ, Schwetye KE, DiPaolo RJ, Brien JD, et al. (2018) PLOS Pathogens 14(9): e1007237. https://doi.org/10.1371/journal.ppat.1007237.
2017
Zika virus pathogenesis in rhesus macaques is unaffected by pre-existing immunity to dengue virus. Pantoja, P., Pérez-Guzmán, E., Rodríguez, I. et al. Nat Commun 8, 15674 (2017). https://doi.org/10.1038/ncomms15674
2016
Residues in the PB2 and PA genes contribute to the pathogenicity of avian H7N3 influenza A virus in DBA/2 mice. Brittany L. DesRochers, Rita E. Chen, Anshu P. Gounder, Amelia K. Pinto, Traci Bricker, Camille N. Linton, Corianne D. Rogers, Graham D. Williams, Richard J. Webby, Adrianus C.M. Boon. Virology, 494, 89-99. (2016) https://doi.org/10.1016/j.virol.2016.04.013
A North American H7N3 Influenza Virus Supports Reassortment with 2009 Pandemic H1N1 and Induces Disease in Mice without Prior Adaptation. Williams, G. D., Pinto, A. K., Doll, B., & Boon, A. Journal of virology, 90(9), 4796–4806 (2016). https://doi.org/10.1128/JVI.02761-15
2015
Interferon-Regulatory Factor 5-Dependent Signaling Restricts Orthobunyavirus Dissemination to the Central Nervous System. Jose Luiz Proenca-Modena, Jennifer L. Hyde, Renata Sesti-Costa, Tiffany Lucas, Amelia K. Pinto, Justin M. Richner, Matthew J. Gorman, Helen M. Lazear, Michael S. Diamond. Journal of Virology 90 (1) 189-205 (2015); DOI: 10.1128/JVI.02276-15
Human and Murine IFIT1 Proteins Do Not Restrict Infection of Negative-Sense RNA Viruses of the Orthomyxoviridae, Bunyaviridae, and Filoviridae Families. Amelia K. Pinto, Graham D. Williams, Kristy J. Szretter, James P. White, José Luiz Proença-Módena, Gai Liu, Judith Olejnik, James D. Brien, Hideki Ebihara, Elke Mühlberger, Gaya Amarasinghe, Michael S. Diamond, Adrianus C. M. Boon. Journal of Virology 89(18) 9465-9476 (2015); DOI: 10.1128/JVI.00996-15
Oropouche Virus Infection and Pathogenesis Are Restricted by MAVS, IRF-3, IRF-7, and Type I Interferon Signaling Pathways in Nonmyeloid Cells. Jose Luiz Proenca-Modena, Renata Sesti-Costa, Amelia K. Pinto, Justin M. Richner, Helen M. Lazear, Tiffany Lucas, Jennifer L. Hyde, Michael S. Diamond. Journal of Virology 89(9) 4720-4737 (2015); DOI: 10.1128/JVI.00077-15
Defining New Therapeutics Using a More Immunocompetent Mouse Model of Antibody-Enhanced Dengue Virus Infection. Amelia K. Pinto, James D. Brien, Chia-Ying Kao Lam, Syd Johnson, Cindy Chiang, John Hiscott, Vanessa V. Sarathy, Alan D. Barrett, Sujan Shresta, Michael S. Diamond. mBio. 6(5) e01316-15 (2015); DOI: 10.1128/mBio.01316-15
Interferon-λ restricts West Nile virus neuroinvasion by tightening the blood-brain barrier. Helen M. Lazear. Brian P. Daniels, Amelia K. Pinto, Albert C. Huang, Sarah C. Vick, Sean E. Doyle, Michael Gale Jr., Robyn S. Klein, and Michael S. Diamond. Science Translational Medicine 22. 7, 284, 284ra59 (2015)
DOI: 10.1126/scitranslmed.aaa4304
2014
Interferon Regulatory Factor 5-Dependent Immune Responses in the Draining Lymph Node Protect against West Nile Virus Infection. Larissa B. Thackray, Bimmi Shrestha, Justin M. Richner, Jonathan J. Miner, Amelia K. Pinto, Helen M. Lazear, Michael Gale Jr., Michael S. Diamond. Journal of Virology 88(19) 11007-11021 (2014); DOI: 10.1128/JVI.01545-14
Deficient IFN Signaling by Myeloid Cells Leads to MAVS-Dependent Virus-Induced Sepsis. Pinto AK, Ramos HJ, Wu X, Aggarwal S, Shrestha B, et al. (2014) PLOS Pathogens 10(4): e1004086. https://doi.org/10.1371/journal.ppat.1004086
c-Myc-induced transcription factor AP4 is required for host protection mediated by CD8+ T cells. Chou, C., Pinto, A., Curtis, J. et al. Nat Immunol 15, 884–893 (2014). https://doi.org/10.1038/ni.2943
A novel T‐cell receptor mimic defines dendritic cells that present an immunodominant West Nile virus epitope in mice. Sojung Kim, Amelia K. Pinto, Nancy B. Myers, Oriana Hawkins, Krysten Doll, Saghar Kaabinejadian, Jason Netland, Michael J. Bevan, Jon A. Weidanz, William H. Hildebrand, Michael S. Diamond, Ted H. Hansen. European Journal of Immunology 44, 7, 1936-1946. (2014) https://doi.org/10.1002/eji.201444450
2013
Murine norovirus infection does not cause major disruptions in the murine intestinal microbiota. Nelson, A.M., Elftman, M.D., Pinto, A.K. et al. Microbiome 1, 7 (2013). https://doi.org/10.1186/2049-2618-1-7
A Hydrogen Peroxide-Inactivated Virus Vaccine Elicits Humoral and Cellular Immunity and Protects against Lethal West Nile Virus Infection in Aged Mice. Amelia K. Pinto, Justin M. Richner, Elizabeth A. Poore, Pradnya P. Patil, Ian J. Amanna, Mark K. Slifka, Michael S. Diamond. Journal of Virology 87(4) 1926-1936 (2013); DOI: 10.1128/JVI.02903-12
Pattern Recognition Receptor MDA5 Modulates CD8+ T Cell-Dependent Clearance of West Nile Virus from the Central Nervous System. Helen M. Lazear, Amelia K. Pinto, Hilario J. Ramos, Sarah C. Vick, Bimmi Shrestha, Mehul S. Suthar, Michael Gale Jr., Michael S. Diamond. Journal of Virology 87(21) 11401-11415 (2013); DOI: 10.1128/JVI.01403-13
2012
CD8+ T Cells Use TRAIL To Restrict West Nile Virus Pathogenesis by Controlling Infection in Neurons. Bimmi Shrestha, Amelia K. Pinto, Sharone Green, Irene Bosch, Michael S. Diamond. Journal of Virology 86(17) 8937-8948 (2012); DOI: 10.1128/JVI.00673-12
RAE1ε Ligand Expressed on Pancreatic Islets Recruits NKG2D Receptor-Expressing Cytotoxic T Cells Independent of T Cell Receptor Recognition. Mary A. Markiewicz, Erica L. Wise, Zachary S. Buchwald, Amelia K. Pinto, Biljana Zafirova, Bojan Polic, Andrey S. Shaw. Immunity 36(1), 132-141 (2012); https://doi.org/10.1016/j.immuni.2011.11.014
2011
A Temporal Role Of Type I Interferon Signaling in CD8+ T Cell Maturation during Acute West Nile Virus Infection. Pinto AK, Daffis S, Brien JD, Gainey MD, Yokoyama WM, et al. (2011) PLOS Pathogens 7(12): e1002407. https://doi.org/10.1371/journal.ppat.1002407
Beta Interferon Controls West Nile Virus Infection and Pathogenesis in Mice. Helen M. Lazear, Amelia K. Pinto, Matthew R. Vogt, Michael Gale Jr., Michael S. Diamond. Journal of Virology 85 (14) 7186-7194 (2011); DOI: 10.1128/JVI.00396-11
Comparing the Kinetics of NK Cells, CD4, and CD8 T Cells in Murine Cytomegalovirus Infection. Timothy E. Schlub, Joseph C. Sun, Senta M. Walton, Scott H. Robbins, Amelia K. Pinto, Michael W. Munks, Ann B. Hill, Laurent Brossay, Annette Oxenius, and Miles P. Davenport. J Immunol 187 (3) 1385-1392 (2011); DOI: https://doi.org/10.4049/jimmunol.1100416
The lectin pathway of complement activation contributes to protection from West Nile virus infection. Anja Fuchs, Amelia K. Pinto, Wilhelm J. Schwaeble, Michael S. Diamond. Virology 412, 1, 101-109 (2011). https://doi.org/10.1016/j.virol.2011.01.003
2009
Effects of Acute and Chronic Murine Norovirus Infections on Immune Responses and Recovery from Friend Retrovirus Infection. Christoph G. Ammann, Ronald J. Messer, Kimberly Varvel, Blair L. DeBuysscher, Rachel A. LaCasse, Amelia K. Pinto, Kim J. Hasenkrug. Journal of Virology. 83 24, 13037-13041 (2009); DOI: 10.1128/JVI.01445-09
Murine Norovirus Infection Has No Significant Effect on Adaptive Immunity to Vaccinia Virus or Influenza A Virus. Scott E. Hensley, Amelia K. Pinto, Heather D. Hickman, Robin J. Kastenmayer, Jack R. Bennink, Herbert W. Virgin, Jonathan W. Yewdell. Journal of Virology. 83, 14, 7357-7360 (2009); DOI: 10.1128/JVI.00623-09
2007
The Role of NKG2D Signaling in Inhibition of Cytotoxic T-Lymphocyte Lysis by the Murine Cytomegalovirus Immunoevasin m152/gp40. Amelia K. Pinto, Amanda M. Jamieson, David H. Raulet, Ann B. Hill. Journal of Virology. 81, 22, 12564-12571 (2007); DOI: 10.1128/JVI.01328-07
Viral Interference with Antigen Presentation Does Not Alter Acute or Chronic CD8 T Cell Immunodominance in Murine Cytomegalovirus Infection. Michael W. Munks, Amelia K. Pinto, Carmen M. Doom and Ann B. Hill. J Immunol. 178, 11, 7235-7241 (2007); DOI: https://doi.org/10.4049/jimmunol.178.11.7235
2006
Coordinated Function of Murine Cytomegalovirus Genes Completely Inhibits CTL Lysis. Amelia K. Pinto, Michael W. Munks, Ulrich H. Koszinowski and Ann B. Hill. J Immunol. 177, 5, 3225-3234 (2006); DOI: https://doi.org/10.4049/jimmunol.177.5.3225
Four Distinct Patterns of Memory CD8 T Cell Responses to Chronic Murine Cytomegalovirus Infection. Michael W. Munks, Kathy S. Cho, Amelia K. Pinto, Sophie Sierro, Paul Klenerman and Ann B. Hill. J Immunol. 177, 1, 450-458 (2006); DOI: https://doi.org/10.4049/jimmunol.177.1.450
Murine Cytomegalovirus Interference with Antigen Presentation Contributes to the Inability of CD8 T Cells To Control Virus in the Salivary Gland. Xiuju Lu, Amelia K. Pinto, Ann M. Kelly, Kathy S. Cho, Ann B. Hill. Journal of Virology. 80, 8, 4200-4202 (2006); DOI: 10.1128/JVI.80.8.4200-4202.2006
2005
2002
Viral Interference with Antigen Presentation to CD8+ T Cells: Lessons from Cytomegalovirus. Amelia K. Pinto and Dr. Ann B. Hill. Viral Immunology. (2005).434-444. http://doi.org/10.1089/vim.2005.18.434
T cell immunodominance and maintenance of memory regulated by unexpectedly cross-reactive pathogens. Brehm, M., Pinto, A., Daniels, K. et al. Nat Immunol 3, 627–634 (2002). https://doi.org/10.1038/ni806
2001
1999
Innate Immunity to Viruses: Control of Vaccinia Virus Infection by γδ T Cells. Liisa K. Selin, Paul A. Santolucito, Amelia K. Pinto, Eva Szomolanyi-Tsuda and Raymond M. Welsh. J Immunol. 166, 11, 6784-6794 (2001); DOI: https://doi.org/10.4049/jimmunol.166.11.6784
Attrition of T Cell Memory: Selective Loss of LCMV Epitope–Specific Memory CD8 T Cells following Infections with Heterologous Viruses. Liisa K Selin, Meei Y Lin, Kristy A Kraemer, Drew M Pardoll, Jonathan P Schneck, Steven M Varga, Paul A Santolucito, Amelia K Pinto, Raymond M Welsh. Immunity. 11, 6, 733-742 (1999); DOI: https://doi.org/10.1016/S1074-7613(00)80147-8
Awards, Meetings & Presentations
Pinto: The Impact of Type I Interferon on Flavivirus Disease Invited Seminar Microbiology Department Western Carolina University, invited speaker, October 5th, 2020
Pinto: COVID-19 Research at Saint Louis University Invited Speaker CORTEX Venture Cafe May 21, 2020
Geerling, E. Second place Saint Louis University Graduate Student Symposium 2022
Geerling, E. , Abstract Award The American Association of Immunologists Annual Meeting 2022
Geerling, E. Conference Award Saint Louis University Graduate Student Association 2021
Geerling, E. Abstract Award The American Association of Immunologists Annual Meeting 2021
Geerling, E. Third place Saint Louis University Graduate Student Symposium 2021
Geerling, E . Second place Saint Louis University Sigma Xi Research Symposium 2021
Geerling, E. Abstract Award Obesity: From Cell to Patient Keystone 2021
Geerling, E. Conference Award Saint Louis University Graduate Student Association 2020
Geerling, E. Research Award Endocrine Society Excellence in Research Award 2020
Hassert, M Best Poster Presentation Saint Louis University Graduate Research Symposium; 2021
Hassert, M Trainee Abstract Award American Association of Immunologists 2021
Hassert, M Young Investigator Award American Society of Tropical Medicine and Hygiene 2020
Hassert, M Travel Award American Society of Tropical Medicine and Hygiene; American Committee on Arthropod-Borne Viruses (ACAV) 2020
Hassert, M Graduate Student of the Year Saint Louis University (MMI Dept.); 2020
Hassert, M Travel Award American Society for Virology 2020
Hassert, M Trainee Abstract Award American Association of Immunologists 2019
Hassert, M Graduate Student of the Year Saint Louis University (MMI Dept.); 2019
Hassert, M Best Poster Presentation Saint Louis University Graduate Research Symposium 2019
Hassert, M Best Poster Presentation Saint Louis University Graduate Research Symposium 2018
Hassert, M Saint Louis University; Alpha Sigma Nu Jesuit Honor Society 2018
Hassert, M Student Fellowship Saõ Paulo School of Advanced Science in Arbovirology; 2017
Stone, E.T., ASV Travel Award 2022
Stone, E.T. .First place Saint Louis University Graduate Student Symposium 2022
Stone, E.T., AAI Trainee Abstract Award Annual Meeting of the American Association of Immunologists 2022
Stone, E.T., Travel award Labroots Scholarship 2022
Stone, E.T., ASV Travel Award 2021
Stone, E.T., Milstein Abstract Award 9th Annual International Cytokine & Interferon Society 2021
Stone, E.T., Awarded AAI Young Investigator Award Autumn Immunology Conference 2019
Stone, E.T., Reinert Teaching Center Foundations Certificate in University Teaching Skills, Expected Fall 2022
Stone, E.T., SLU Chapter Public Relations Representative American Society for Microbiology 2021 - 2022
Stone, E.T., SLU Adjunct Instructor BIOL 1240, General Biology: Information Flow and Evolution Fall 2021
Stone, E.T., Supporting Sponsor-Attendee ComSciCon—Combatting COVID-19 within Black Communities June 2021
Stone, E.T., Curriculum Coordinator Young Scientists Program 2020 - 2021
Stone, E.T., Cohort Liaison Young Scientists Program 2019 - 2020
Stone, E.T., American Committee Arthropod-borne viruses Travel Award 2019